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This observation is intriguing for 2 other factors. First, it indicates that cells will take up MIF by ENDOCYTOSIS. offered the considerable intracellular expression of MIF, it might be questioned what gain would the mobile acquire by making use of endocytosed MIF instead of intracellular MIF. Endocytosis of MIF may possibly arise either within a r
A modern discovery highlighted a novel position for intracellular MIF in regulating the accumulation of misfolded Cu/Zn superoxide dismutase (SOD1). Mutations in SOD1 are related to 20% from the cases of familial amyotrophic lateral sclerosis, which is characterised by loss of motor neurons [seventy two]. the truth is, you'll find three additional